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SCHEMBL4189603

SCHEMBL4189603

Cc1c[nH]c2c(-c3c(F)cc4c(c3F)/C(=N/OC(C)(C)C(=O)O)CC(C)(C)N4)cccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 20/20 1.00
▸ PGR P06401 9/20 0.82
▸ NR3C2 P08235 8/20 0.82
▸ AR P10275 6/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4188377 0.92 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL13747878 0.91 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL13747742 0.91 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL4559897 0.90 NR3C1 (0.85) NR3C1PGRNR3C2AR
SCHEMBL4204732 0.89 NR3C1 (0.80) NR3C1PGRNR3C2AR
SCHEMBL13747594 0.89 NR3C1 (0.80) NR3C1PGRNR3C2AR
SCHEMBL4540162 0.88 NR3C1 (1.00) NR3C1PGRNR3C2AR
SCHEMBL4204006 0.88 NR3C1 (0.82) NR3C1PGRNR3C2AR
SCHEMBL4200963 0.88 NR3C1 (0.78) NR3C1PGRNR3C2AR
SCHEMBL4200964 0.88 NR3C1 (0.78) NR3C1PGRNR3C2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009103007-A2 STEROID HORMONE RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-08-20 — — WO disclosed
WO-2009103007-A2 STEROID HORMONE RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-08-20 — — WO disclosed
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