Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581132 | 0.80 | SMN1; SMN2 (0.56) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL204057 | 0.73 | DDAH1 (0.48) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL10258501 | 0.69 | L3MBTL1 (0.45) | MGLLKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL31456716 | 0.69 | GAA (0.51) | KMOKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9977167 | 0.68 | KMT2A (0.49) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL14694425 | 0.66 | POLB (0.40) | KMOKDM4EKMT2AALDH1A1GAA | |
| SCHEMBL23574426 | 0.66 | CA12 (0.49) | ALDH1A1TDP1LMNAGAASMN1; SMN2 | |
| SCHEMBL1256450 | 0.65 | CREBBP (0.42) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL4688563 | 0.65 | MYC (0.54) | KDM4EKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL4993099 | 0.65 | TTR (0.42) | KDM4EKMT2AMEN1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | disclosed |