Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13909387 | 1.00 | HPGD (0.55) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL2898601 | 1.00 | HPGD (0.55) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL5001754 | 0.86 | HPGD (0.62) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL11448045 | 0.86 | HPGD (0.62) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL29451127 | 0.86 | HPGD (0.62) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL30634941 | 0.86 | HPGD (0.62) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL5001755 | 0.86 | HPGD (0.62) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL16108470 | 0.84 | HPGD (0.52) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL21752371 | 0.84 | SMN1; SMN2 (0.52) | HPGDMAPK1CYP1A2NPSR1NPC1 | |
| SCHEMBL21752369 | 0.84 | SMN1; SMN2 (0.52) | HPGDMAPK1CYP1A2NPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101646652-A | Quinoline derivatives and pharmaceutical compositions comprising them for selectin inhibition | WYETH CORP US | 2010-02-10 | — | — | CN | disclosed |
| EP-2134692-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-23 | — | — | EP | disclosed |
| EP-2132180-A1 | METHODS AND COMPOSITIONS FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-16 | — | — | EP | disclosed |
| US-20090076077-A1 | Methods and Compositions for Selectin Inhibition | WYETH (US) | 2009-03-19 | — | — | US | disclosed |
| US-7465799-B2 | Methods and compositions for selectin inhibition | WYETH (US) | 2008-12-16 | — | — | US | disclosed |
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008121805-A1 | METHODS AND COMPOSITIONS FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008121817-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |
| US-20080242700-A1 | Methods and Compositions for Selectin Inhibition | WYETH (US) | 2008-10-02 | — | — | US | disclosed |
| EP-1682511-A2 | METHODS AND COMPOSITIONS FOR SELECTIN INHIBITION | Wyeth (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047257-A2 | METHODS AND COMPOSITIONS FOR SELECTIN INHIBITION | WYETH (US) | 2005-05-26 | — | — | WO | disclosed |
| US-20050101568-A1 | Methods and compositions for selectin inhibition | WYETH (US) | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101568-A1 | Methods and compositions for selectin inhibition | SELP, SELE, SELL | HPGD 411/4885MAPK1 1839/4885CYP1A2 1507/4885 |
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | VCAM1, ICAM1, SELE | HPGD 244/4885MAPK1 1955/4885CYP1A2 2083/4885 |
| US-20090076077-A1 | Methods and Compositions for Selectin Inhibition | SELP, SELE, SELL | HPGD 459/4885MAPK1 1852/4885CYP1A2 1790/4885 |
| US-20080242700-A1 | Methods and Compositions for Selectin Inhibition | SELE, SELP, SELL | HPGD 399/4885MAPK1 2535/4885CYP1A2 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.