Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 7/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | RARA | P10276 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | MTOR | P42345 | 1/20 | 0.69 |
| ▸ | PLK1 | P53350 | 3/20 | 0.59 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.58 |
| ▸ | THRA | P10827 | 5/20 | 0.56 |
| ▸ | THRB | P10828 | 5/20 | 0.56 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709309 | 0.95 | PLK1 (0.65) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL9206725 | 0.95 | PLK1 (0.65) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL9164847 | 0.95 | PLK1 (0.65) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL15174597 | 0.95 | PLK1 (0.65) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL4824490 | 0.95 | PLK1 (0.65) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL2747801 | 0.94 | PLK1 (0.67) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL19443009 | 0.89 | PLK1 (0.74) | RARBALDH1A1MAPTPLK1SPHK2 | |
| SCHEMBL23484726 | 0.88 | PLK1 (0.79) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL4185605 | 0.88 | RARB (0.69) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL2831713 | 0.87 | TRPV1 (0.68) | PLK1SPHK1THRATHRBPLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220296579-A1 | COMPOSITIONS AND METHODS FOR PROVIDING CARDIOPROTECTIVE EFFECTS | CORNELL UNIVERSITY (US) | 2022-09-22 | — | — | US | disclosed |
| US-11191755-B2 | Compositions and methods for providing cardioprotective effects | CORNELL UNIVERSITY (US) | 2021-12-07 | — | — | US | disclosed |
| US-11160769-B2 | Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists | CORNELL UNIVERSITY (US) | 2021-11-02 | — | — | US | disclosed |
| EP-3094380-B1 | METHODS OF TREATING METABOLIC SYNDROME RELATED CONDITIONS USING RETINOIC ACID RECEPTOR AGONISTS | UNIV CORNELL (US) | 2021-04-28 | — | — | EP | disclosed |
| US-20090176837-A1 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | SONY CORPORATION (JP) | 2009-07-09 | — | — | US | disclosed |
| US-20090176837-A1 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | SONY CORPORATION (JP) | 2009-07-09 | — | — | US | disclosed |
| US-20090176837-A1 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | SONY CORPORATION (JP) | 2009-07-09 | — | — | US | disclosed |
| WO-2007009083-A2 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220296579-A1 | COMPOSITIONS AND METHODS FOR PROVIDING CARDIOPROTECTIVE EFFECTS | RARB, RARG, RARA | RARB 1/4885MEN1 4881/4885KMT2A 4014/4885 |
| US-11191755-B2 | Compositions and methods for providing cardioprotective effects | RARB, RARG, RARA | RARB 1/4885MEN1 4881/4885KMT2A 4014/4885 |
| US-11160769-B2 | Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists | RARA, RARG, RXRA | RARB 5/4885MEN1 3112/4885KMT2A 2273/4885 |
| US-20090176837-A1 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | RARB, RARA, RARG | RARB 1/4885MEN1 4845/4885KMT2A 2499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.