Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.79 |
| ▸ | C1R | P00736 | 8/20 | 0.71 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | KLK1 | P06870 | 1/20 | 0.49 |
| ▸ | C1S | P09871 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984780 | 0.88 | ELANE (1.00) | ELANEC1RPBRM1KMT2APRSS1 | |
| SCHEMBL4192197 | 0.83 | C1R (0.71) | ELANEC1R | |
| SCHEMBL29849973 | 0.83 | ELANE (1.00) | ELANEC1RPBRM1KMT2AF2 | |
| SCHEMBL9984776 | 0.83 | ELANE (1.00) | ELANEC1RPBRM1KMT2AF2 | |
| SCHEMBL9984683 | 0.83 | ELANE (1.00) | ELANEC1RPBRM1KMT2AMEN1 | |
| SCHEMBL29574035 | 0.83 | ELANE (1.00) | ELANEC1RPBRM1KMT2APRSS1 | |
| SCHEMBL9985824 | 0.83 | ELANE (1.00) | ELANEC1RPBRM1KMT2APRSS1 | |
| SCHEMBL20176382 | 0.83 | ELANE (0.73) | ELANEC1RPBRM1KMT2APRSS1 | |
| SCHEMBL2816912 | 0.82 | C1R (0.69) | ELANEC1RKMT2APRSS1F2 | |
| SCHEMBL9986142 | 0.80 | ELANE (1.00) | ELANEC1RPBRM1PRSS1CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |