SCHEMBL4190777

SCHEMBL4190777

Cc1cccc(C(O)(C(=O)OCC2C3CCC2CNC3)c2cccc(C)c2)c1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.41
CHRM3 P20309 5/20 0.39
CHRM2 P08172 3/20 0.39
SSTR4 P31391 1/20 0.36
CYP2D6 P10635 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
SLC6A4 P31645 1/20 0.36
KCNH2 Q12809 1/20 0.36
KIF11 P52732 3/20 0.34
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4878736 0.88 LMNA (0.43) LMNACHRM3CHRM2SSTR4CHRM4
SCHEMBL4191418 0.86 CHRM3 (0.51) CHRM3CHRM2CYP2D6CHRM4CHRM5
SCHEMBL3216742 0.86 CHRM3 (0.46) CHRM3CHRM2CYP2D6CHRM4CHRM5
SCHEMBL4190902 0.79 CHRM3 (0.56) CHRM3CHRM2CHRM1ALDH1A1
SCHEMBL4200185 0.78 CHRM3 (0.45) CHRM3CHRM2SSTR4CHRM4CHRM5
SCHEMBL4194973 0.76 HTR2C (0.37) LMNACHRM3CHRM2SSTR4CYP2D6
SCHEMBL4620005 0.74 ALDH1A1 (0.48) LMNACHRM3CHRM2CHRM4CHRM5
SCHEMBL3222037 0.74 CHRM2 (0.45) LMNACHRM3CHRM2CYP2D6CHRM4
SCHEMBL4620934 0.72 CHRM3 (0.38) CHRM3CHRM2SSTR4CYP2D6CHRM4
SCHEMBL4619183 0.72 LMNA (0.53) LMNASSTR4SLC6A4KIF11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090105221-A1 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2009-04-23 US claimed
EP-1797040-A1 MUSCARINIC RECEPTOR ANTAGONISTS Ranbaxy Laboratories Limited (IN) 2007-06-20 EP claimed
WO-2006035303-A1 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2006-04-06 WO claimed
US-20090105221-A1 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2009-04-23 US disclosed
US-20090105221-A1 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2009-04-23 US disclosed
US-20090105221-A1 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2009-04-23 US disclosed
EP-1797040-A1 MUSCARINIC RECEPTOR ANTAGONISTS Ranbaxy Laboratories Limited (IN) 2007-06-20 EP disclosed
WO-2006035303-A1 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2006-04-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090105221-A1 MUSCARINIC RECEPTOR ANTAGONISTS CHRM3, CHRM5, CHRM2 LMNA 2026/4885CHRM3 1/4885CHRM2 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.