Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 3/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1092228 | 0.85 | PDE4A (0.33) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL1094081 | 0.85 | PDE4A (0.33) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL1092157 | 0.85 | PDE4D (0.32) | AKR1C2AKR1C1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL209090 | 0.81 | XDH (0.33) | XDHAKR1C2AKR1C1PRKAB2PRKAG1 | |
| SCHEMBL1093033 | 0.81 | PSD (0.34) | HRH3KCNH2 | |
| SCHEMBL1092147 | 0.80 | PSD (0.35) | HRH3KCNH2 | |
| SCHEMBL208541 | 0.74 | SRD5A2 (0.32) | AKR1C2AKR1C1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4060990 | 0.74 | SRD5A2 (0.32) | AKR1C2AKR1C1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4197218 | 0.73 | CHEK2 (0.36) | MEN1KMT2A | |
| SCHEMBL1091969 | 0.72 | SCN1A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |