Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 7/20 | 0.73 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27908055 | 0.99 | MAPK1 (0.74) | MAPK1ALOX15RAB9ANPC1KCNMA1 | |
| SCHEMBL4286353 | 0.91 | ADORA2A (0.73) | MAPK1ALOX15RAB9ANPC1KCNMA1 | |
| SCHEMBL2380796 | 0.87 | MAPK1 (0.60) | MAPK1ALOX15RAB9ANPC1KCNMA1 | |
| SCHEMBL714175 | 0.86 | MAPK1 (0.73) | MAPK1ALOX15RAB9ANPC1MAPT | |
| SCHEMBL16363830 | 0.86 | MAPK1 (1.00) | MAPK1ALOX15RAB9ANPC1MAPT | |
| SCHEMBL24934051 | 0.85 | RAB9A (0.72) | MAPK1ALOX15RAB9ANPC1KCNMA1 | |
| SCHEMBL16078340 | 0.84 | RAB9A (0.64) | MAPK1ALOX15RAB9ANPC1KCNMA1 | |
| SCHEMBL17274993 | 0.84 | MAPK1 (0.81) | MAPK1ALOX15RAB9ANPC1CYP1A2 | |
| SCHEMBL12443375 | 0.84 | RAB9A (1.00) | MAPK1ALOX15RAB9ANPC1KCNMA1 | |
| SCHEMBL703469 | 0.84 | ALOX15 (0.70) | MAPK1ALOX15RAB9ANPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | 4SC AG (DE) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | NFKB2, NFKBIA, NFRKB | MAPK1 1515/4885ALOX15 2365/4885RAB9A 3958/4885 |
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | NFKB2, NFKBIA, NFRKB | MAPK1 1515/4885ALOX15 2365/4885RAB9A 3958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.