Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 3/20 | 0.55 |
| ▸ | CCNK | O75909 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CCND1 | P24385 | 2/20 | 0.53 |
| ▸ | CCND2 | P30279 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | STAT6 | P42226 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 6/20 | 0.48 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4515832 | 0.83 | CCND3 (0.57) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL4189970 | 0.80 | STAT6 (0.65) | CCND3CCNA2CDK2CDK4CCND1 | |
| SCHEMBL11976969 | 0.80 | CDK4 (0.68) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL16580961 | 0.79 | CCND3 (0.54) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL17958712 | 0.79 | CCND3 (0.51) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL23247497 | 0.77 | WEE1 (0.60) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL17958734 | 0.77 | CCND3 (0.51) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL4200620 | 0.77 | CDK4 (0.51) | CCND3CDK2CDK4CCND1CCND2 | |
| SCHEMBL16569980 | 0.77 | CCND3 (0.50) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL23444641 | 0.76 | JAK3 (0.76) | CCND3CDK4CCND1CCND2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |