Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 7/20 | 0.65 |
| ▸ | CDK4 | P11802 | 6/20 | 0.56 |
| ▸ | CCND1 | P24385 | 6/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.52 |
| ▸ | CCND2 | P30279 | 3/20 | 0.52 |
| ▸ | CCND3 | P30281 | 3/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.51 |
| ▸ | BRD4 | O60885 | 5/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | BRD2 | P25440 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200620 | 0.82 | CDK4 (0.51) | STAT6CDK4CCND1CDK2FGFR4 | |
| SCHEMBL4189887 | 0.82 | CDK4 (0.54) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL4192080 | 0.80 | CCND3 (0.55) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15163242 | 0.80 | STAT6 (0.67) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL4342366 | 0.80 | CDK4 (0.60) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL11977047 | 0.79 | CDK4 (0.62) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL3790571 | 0.78 | STAT6 (0.68) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL4191050 | 0.77 | CDK4 (0.50) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL27844369 | 0.77 | STAT6 (0.69) | STAT6CDK4CCND1CCNA2CDK2 | |
| SCHEMBL16570745 | 0.77 | STAT6 (0.57) | STAT6CDK4CCND1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |