Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4197439 | 0.91 | MAPK14 (0.48) | MAPK14POLBFKBP1AACLYALDH1A1 | |
| SCHEMBL3748047 | 0.88 | MAPK14 (0.46) | MAPK14POLBFKBP1AACLYALDH1A1 | |
| SCHEMBL4190078 | 0.84 | MAPK14 (0.43) | MAPK14POLBFKBP1AACLYALDH1A1 | |
| SCHEMBL4191639 | 0.83 | MAPK14 (0.45) | MAPK14POLBFKBP1AALDH1A1LMNA | |
| SCHEMBL282424 | 0.73 | THRB (0.44) | POLBFKBP1AALDH1A1LMNAMEN1 | |
| SCHEMBL2329034 | 0.65 | LMNA (0.50) | ALDH1A1LMNAMEN1KMT2AGAA | |
| SCHEMBL282166 | 0.63 | THRB (0.44) | POLBFKBP1ALMNAMEN1KMT2A | |
| SCHEMBL23752377 | 0.62 | MAPK14 (1.00) | MAPK14FKBP1AMAP2K1KMT2AFAAH | |
| SCHEMBL282039 | 0.61 | THRB (0.53) | POLBFKBP1AALDH1A1LMNAMEN1 | |
| SCHEMBL31597071 | 0.60 | RYR2 (0.53) | FKBP1AALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689383-A4 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1689383-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051298-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2005-06-09 | — | — | WO | disclosed |