Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | SOD3 | P08294 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12282789 | 0.83 | PDCD1 (0.43) | PDCD1CD274SOD3 | |
| Hydrochloric Acid SCHEMBL27147176 | 0.81 | PDCD1 (0.42) | PDCD1CD274SOD3 | |
| SCHEMBL23652744 | 0.81 | PDCD1 (0.42) | PDCD1CD274SOD3 | |
| SCHEMBL1684264 | 0.81 | PDCD1 (0.39) | PDCD1CD274SOD3 | |
| SCHEMBL30915369 | 0.78 | PDCD1 (0.40) | PDCD1CD274SOD3 | |
| SCHEMBL25410303 | 0.78 | BAZ2B (0.43) | PDCD1CD274SOD3 | |
| SCHEMBL26093107 | 0.78 | PLAT (0.41) | PDCD1CD274 | |
| SCHEMBL2522852 | 0.74 | PDCD1 (0.43) | PDCD1CD274 | |
| SCHEMBL30699672 | 0.74 | PDCD1 (0.39) | PDCD1CD274 | |
| SCHEMBL10289434 | 0.74 | PDCD1 (0.41) | PDCD1CD274SOD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476666-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080015187-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015187-A1 | Hiv Integrase Inhibitors | REV1, ZC3HAV1, PNP | PDCD1 1322/4885CD274 1940/4885SOD3 3414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.