Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479819 | 0.89 | KMT2A (0.47) | KMT2AMEN1WNT1GSK3BDYRK1A | |
| SCHEMBL2421857 | 0.84 | KMT2A (0.52) | KMT2AMEN1PKMNPC1APOBEC3A | |
| SCHEMBL2422939 | 0.84 | KMT2A (0.53) | KMT2AMEN1SLC5A7PKMNPC1 | |
| SCHEMBL2423231 | 0.84 | KMT2A (0.55) | KMT2AMEN1PKMNPC1RAB9A | |
| SCHEMBL7443445 | 0.83 | ALDH1A1 (0.46) | KMT2AMEN1PKMNPC1APOBEC3A | |
| SCHEMBL7445343 | 0.80 | MEN1 (0.39) | KMT2AMEN1WNT1GSK3BDYRK1A | |
| SCHEMBL7438443 | 0.80 | KMT2A (0.48) | KMT2AMEN1PKMNPC1RAB9A | |
| SCHEMBL2424314 | 0.80 | KMT2A (0.53) | KMT2AMEN1PKMNPC1MAPK9 | |
| SCHEMBL2423174 | 0.79 | KMT2A (0.59) | KMT2AMEN1PKMNPC1RAB9A | |
| SCHEMBL2425856 | 0.79 | KMT2A (0.54) | KMT2AMEN1PKMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |