Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4211817 | 0.77 | SLC6A4 (0.44) | SLC6A4HTR6GLASLC6A2 | |
| SCHEMBL4193528 | 0.77 | SLC6A4 (0.44) | SLC6A4HTR6GLASLC6A2 | |
| SCHEMBL17593113 | 0.73 | CA1 (0.45) | KDM4E | |
| SCHEMBL17593112 | 0.73 | CA1 (0.45) | KDM4E | |
| SCHEMBL24767003 | 0.72 | ALDH1A1 (0.49) | SLC6A4GLAKDM4ETDP1 | |
| SCHEMBL2580468 | 0.71 | SLC6A4 (0.64) | SLC6A4HTR6 | |
| SCHEMBL4572874 | 0.68 | KDM4E (0.59) | GLAKDM4ETDP1 | |
| SCHEMBL14862428 | 0.68 | SLC6A4 (0.64) | SLC6A4HTR6 | |
| SCHEMBL129918 | 0.68 | PDE4B (0.49) | — | |
| SCHEMBL30350487 | 0.68 | PDE4B (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029609-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | Eli Lilly & Company (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007146758-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-12-21 | — | — | WO | disclosed |