Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 5/20 | 0.32 |
| ▸ | TACR1 | P25103 | 3/20 | 0.32 |
| ▸ | TACR2 | P21452 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428330 | 0.86 | ESR2 (0.44) | P2RX7ESR1KMT2AESR2 | |
| SCHEMBL4182389 | 0.86 | P2RX7 (0.41) | P2RX7TACR3TACR1TACR2KCNH2 | |
| SCHEMBL3816917 | 0.84 | TACR3 (0.41) | TACR3TACR1TACR2KCNH2CYP1A2 | |
| SCHEMBL3819604 | 0.84 | TACR3 (0.36) | TACR3TACR1TACR2KCNH2ESR1 | |
| SCHEMBL3820997 | 0.84 | DPP4 (0.47) | P2RX7DPP4DPP8DPP9PARP1 | |
| SCHEMBL3819398 | 0.84 | DPP4 (0.45) | P2RX7DPP4DPP8DPP9PARP1 | |
| SCHEMBL4171241 | 0.82 | P2RX7 (0.40) | P2RX7TACR3TACR1TACR2KCNH2 | |
| SCHEMBL3822227 | 0.81 | TACR3 (0.43) | P2RX7TACR3TACR1TACR2KCNH2 | |
| SCHEMBL3822498 | 0.79 | TACR3 (0.39) | TACR3TACR1TACR2KCNH2CYP1A2 | |
| SCHEMBL4187598 | 0.78 | P2RX7 (0.34) | P2RX7TACR3TACR1TACR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |