Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.34 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 8/20 | 0.33 |
| ▸ | TACR1 | P25103 | 4/20 | 0.33 |
| ▸ | TACR2 | P21452 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426577 | 0.87 | ALDH1A1 (0.40) | — | |
| SCHEMBL4171241 | 0.83 | P2RX7 (0.40) | P2RX7TACR3TACR1TACR2KCNH2 | |
| SCHEMBL3813972 | 0.81 | ALDH1A1 (0.36) | EIF4A3TACR3TACR1TACR2 | |
| SCHEMBL3815452 | 0.81 | TACR3 (0.39) | P2RX7TACR3TACR1TACR2KCNH2 | |
| SCHEMBL3812475 | 0.80 | TACR3 (0.46) | P2RX7TACR3TACR1TACR2KCNH2 | |
| SCHEMBL3817030 | 0.80 | TACR3 (0.40) | TACR3TACR1TACR2KCNH2CYP1A2 | |
| SCHEMBL4182389 | 0.80 | P2RX7 (0.41) | P2RX7EIF4A3TACR3TACR1TACR2 | |
| SCHEMBL3818664 | 0.80 | P2RX7 (0.48) | P2RX7 | |
| SCHEMBL3820350 | 0.80 | P2RX7 (0.44) | P2RX7 | |
| SCHEMBL3814566 | 0.79 | P2RX7 (0.48) | P2RX7TACR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |