Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCKDK | O14874 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.34 |
| ▸ | SELE | P16581 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PMM2 | O15305 | 2/20 | 0.33 |
| ▸ | MPI | P34949 | 2/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342850 | 0.79 | CMA1 (0.41) | BCKDKMTNR1AMTNR1BCMA1PMM2 | |
| SCHEMBL4188868 | 0.74 | PTGDR2 (0.41) | BCKDKMTNR1AMTNR1B | |
| SCHEMBL4605894 | 0.71 | ESR1 (0.40) | CMA1KMT2ANPC1RAB9AESR1 | |
| SCHEMBL15698889 | 0.69 | CFTR (0.43) | DYRK1AMAPTKMT2ATP53KDM4E | |
| SCHEMBL9541007 | 0.68 | KDM4E (0.47) | MAPTKMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL6963675 | 0.68 | CMA1 (0.46) | BCKDKMTNR1AMTNR1BDYRK1ACMA1 | |
| SCHEMBL14293108 | 0.68 | BCKDK (0.58) | BCKDKMAPTNPC1RAB9ATP53 | |
| SCHEMBL4603763 | 0.68 | MAOB (0.44) | ICAM1SELEVCAM1MAPTKMT2A | |
| SCHEMBL4191239 | 0.68 | POLB (0.46) | MTNR1AMTNR1BMAPTKMT2AKDM4E | |
| SCHEMBL17149278 | 0.68 | LMNA (0.44) | ICAM1SELEVCAM1CMA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664011-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1664011-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020917-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |