Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | LIPE | Q05469 | 9/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011736 | 0.93 | THRB (0.50) | THRBLIPEL3MBTL1MAPK1LMNA | |
| SCHEMBL1011707 | 0.90 | THRB (0.63) | THRBLIPEL3MBTL1MAPK1LMNA | |
| SCHEMBL1417238 | 0.85 | THRB (0.69) | THRBLIPEL3MBTL1MAPK1LMNA | |
| SCHEMBL1011722 | 0.81 | LIPE (0.50) | THRBLIPEMAPK1LMNAMAPT | |
| SCHEMBL2424855 | 0.78 | MAPK1 (0.62) | THRBLIPEL3MBTL1MAPK1LMNA | |
| SCHEMBL16188792 | 0.77 | LIPE (0.59) | THRBLIPEMAPK1LMNAMAPT | |
| SCHEMBL31360509 | 0.76 | THRB (0.61) | THRBLIPEL3MBTL1MAPK1LMNA | |
| SCHEMBL31360386 | 0.76 | THRB (0.61) | THRBLIPEL3MBTL1MAPK1LMNA | |
| SCHEMBL1013808 | 0.76 | THRB (0.61) | THRBLIPEL3MBTL1MAPK1LMNA | |
| SCHEMBL1011792 | 0.76 | THRB (0.57) | THRBLIPEL3MBTL1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076508-A2 | BIARYL ETHER UREA COMPOUNDS | Pfizer Products Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008047229-A2 | BIARYL ETHER UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |