Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11311256 | 0.82 | TDP1 (0.53) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL69234 | 0.82 | TDP1 (0.76) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL29564952 | 0.82 | TDP1 (0.76) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL11248912 | 0.80 | TDP1 (0.50) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL11261355 | 0.80 | TDP1 (0.50) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL11251835 | 0.80 | TDP1 (0.54) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL11261303 | 0.78 | TDP1 (0.49) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL11249116 | 0.77 | TDP1 (0.47) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL11260439 | 0.77 | TDP1 (0.47) | TDP1KDM4EMAPTCYP1A2AKR1B1 | |
| SCHEMBL3064043 | 0.77 | KDM4E (0.65) | TDP1KDM4EMAPTCYP1A2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |