Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267832 | 0.94 | TDP1 (0.45) | TDP1CYP1A2KDM4EMAPTAKR1B1 | |
| SCHEMBL11269174 | 0.94 | TDP1 (0.45) | TDP1CYP1A2KDM4EMAPTAKR1B1 | |
| SCHEMBL11252606 | 0.93 | TDP1 (0.44) | TDP1CYP1A2KDM4EMAPTAKR1B1 | |
| SCHEMBL11266460 | 0.81 | CDK5 (0.38) | TDP1KDM4ECDK2GLACCNE1 | |
| SCHEMBL19099076 | 0.80 | KDM4E (0.56) | TDP1CYP1A2KDM4EMAPTAKR1B1 | |
| SCHEMBL4194024 | 0.77 | TDP1 (0.54) | TDP1CYP1A2KDM4EMAPTAKR1B1 | |
| SCHEMBL11261376 | 0.77 | KDM4E (0.41) | TDP1KDM4EMAPTCDK5 | |
| SCHEMBL11263232 | 0.76 | PKM (0.40) | TDP1KDM4EMAPT | |
| SCHEMBL11311256 | 0.76 | TDP1 (0.53) | TDP1CYP1A2KDM4EMAPTAKR1B1 | |
| SCHEMBL69234 | 0.76 | TDP1 (0.76) | TDP1CYP1A2KDM4EMAPTAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |