Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 13/20 | 0.67 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13747782 | 0.82 | SCARB1 (0.66) | SCARB1HRH1HTR6 | |
| SCHEMBL4195391 | 0.82 | SCARB1 (0.72) | SCARB1HRH1HTR6RORC | |
| SCHEMBL4193417 | 0.81 | SCARB1 (0.46) | SCARB1HRH1HTR6CHRM2HTR1A | |
| SCHEMBL4204690 | 0.81 | SCARB1 (1.00) | SCARB1 | |
| SCHEMBL4195483 | 0.81 | SCARB1 (0.64) | SCARB1HRH1HTR6HRH2HRH3 | |
| SCHEMBL13747174 | 0.80 | SCARB1 (0.63) | SCARB1HRH1HTR6RORCCHRM2 | |
| SCHEMBL13746615 | 0.80 | SCARB1 (1.00) | SCARB1HRH1HTR6RORCCHRM2 | |
| SCHEMBL13747535 | 0.80 | SCARB1 (0.63) | SCARB1HRH1HTR6RORCCHRM2 | |
| SCHEMBL541977 | 0.79 | RORC (0.59) | SCARB1HRH1HTR6RORCCA1 | |
| SCHEMBL13747173 | 0.78 | SCARB1 (0.58) | SCARB1HRH1HTR6RORCCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |