Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 17/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4195483 | 0.88 | SCARB1 (0.64) | SCARB1CYP3A4HRH1HTR6 | |
| SCHEMBL4195391 | 0.88 | SCARB1 (0.72) | SCARB1CYP3A4HRH1HTR6 | |
| SCHEMBL4194079 | 0.82 | SCARB1 (0.67) | SCARB1HRH1HTR6 | |
| SCHEMBL4204690 | 0.80 | SCARB1 (1.00) | SCARB1 | |
| SCHEMBL4200984 | 0.80 | SCARB1 (0.68) | SCARB1 | |
| SCHEMBL13747535 | 0.73 | SCARB1 (0.63) | SCARB1HRH1HTR6 | |
| SCHEMBL13746615 | 0.73 | SCARB1 (1.00) | SCARB1HRH1HTR6 | |
| SCHEMBL13747174 | 0.73 | SCARB1 (0.63) | SCARB1HRH1HTR6 | |
| SCHEMBL541977 | 0.72 | RORC (0.59) | SCARB1HRH1HTR6 | |
| SCHEMBL4201950 | 0.72 | SCARB1 (0.66) | SCARB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |