Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.60 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 2/20 | 0.47 |
| ▸ | KDM4B | O94953 | 2/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310313 | 0.87 | NPC1 (0.64) | MAPTSMN1; SMN2PARP1LMNATSHR | |
| SCHEMBL20662871 | 0.79 | MAPT (1.00) | MAPTSMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL21066336 | 0.76 | L3MBTL1 (0.54) | MAPTSMN1; SMN2MAPK1LMNARAB9A | |
| SCHEMBL704723 | 0.75 | SMN1; SMN2 (1.00) | MAPTSMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL689416 | 0.74 | L3MBTL1 (0.72) | MAPTSMN1; SMN2MAPK1LMNAHSD17B10 | |
| SCHEMBL7136797 | 0.74 | L3MBTL1 (0.49) | MAPTSMN1; SMN2MAPK1HSD17B10RAB9A | |
| SCHEMBL17107144 | 0.74 | PARP1 (1.00) | PARP1MAPK1LMNATSHRHSD17B10 | |
| SCHEMBL3603304 | 0.74 | NPC1 (0.68) | MAPTSMN1; SMN2PARP1LMNATSHR | |
| SCHEMBL20662872 | 0.73 | MAPT (0.64) | MAPTSMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL12249044 | 0.73 | PARP1 (0.78) | MAPTSMN1; SMN2PARP1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | 4SC AG (DE) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | NFKB2, NFKBIA, NFRKB | MAPT 4818/4885SMN1; SMN2 3959/4885TAS1R3 3511/4885 |
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | NFKB2, NFKBIA, NFRKB | MAPT 4818/4885SMN1; SMN2 3959/4885TAS1R3 3511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.