Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.69 |
| ▸ | CNR2 | P34972 | 8/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224036 | 0.87 | CNR1 (0.74) | CNR1CNR2AURKALCKMET | |
| SCHEMBL4199022 | 0.83 | CNR1 (0.64) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL5224040 | 0.82 | CNR1 (0.78) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL5314765 | 0.82 | CNR1 (0.78) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4190780 | 0.82 | CNR1 (1.00) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4190849 | 0.82 | CNR1 (0.78) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL5220662 | 0.82 | CNR1 (0.74) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4194677 | 0.81 | CNR1 (0.73) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4191810 | 0.79 | CNR1 (0.73) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4185327 | 0.79 | CNR1 (0.73) | CNR1CNR2NPC1ALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |