Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 11/20 | 0.78 |
| ▸ | CNR2 | P34972 | 10/20 | 0.78 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190849 | 0.88 | CNR1 (0.78) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL5314765 | 0.88 | CNR1 (0.78) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4190780 | 0.88 | CNR1 (1.00) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL5220662 | 0.85 | CNR1 (0.74) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL5224036 | 0.85 | CNR1 (0.74) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4185327 | 0.84 | CNR1 (0.73) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4194677 | 0.84 | CNR1 (0.73) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4191810 | 0.84 | CNR1 (0.73) | CNR1CNR2NPC1ALDH1A1BCHE | |
| SCHEMBL4194303 | 0.82 | CNR1 (0.90) | CNR1CNR2NPC1ALDH1A1GFER | |
| SCHEMBL4196133 | 0.82 | CNR1 (0.69) | CNR1CNR2NPC1ALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |