Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 14/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187155 | 0.91 | NQO1 (0.40) | SLC22A12NQO1MTNR1AMTNR1BKDM4E | |
| SCHEMBL4196169 | 0.78 | KDM4E (0.45) | SLC22A12NQO1KDM4ENPC1ALDH1A1 | |
| SCHEMBL4179943 | 0.77 | KDM4E (0.50) | SLC22A12NQO1KDM4ENPC1ALDH1A1 | |
| SCHEMBL4179901 | 0.72 | KDM4E (0.39) | SLC22A12MTNR1AMTNR1BKDM4ENPC1 | |
| SCHEMBL4187152 | 0.68 | KDM4E (0.47) | NQO1MTNR1AMTNR1BKDM4ENPC1 | |
| SCHEMBL4192786 | 0.67 | ICAM1 (0.36) | KDM4ENPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL4188710 | 0.65 | MTNR1A (0.46) | SLC22A12NQO1MTNR1AMTNR1BKDM4E | |
| SCHEMBL4193928 | 0.63 | SLC22A12 (0.41) | SLC22A12NQO1MTNR1AMTNR1BKDM4E | |
| SCHEMBL4193929 | 0.63 | MTNR1A (0.49) | MTNR1AMTNR1B | |
| SCHEMBL4188707 | 0.61 | NQO1 (0.43) | SLC22A12NQO1MTNR1AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664011-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1664011-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020917-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |