Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187155 | 0.79 | NQO1 (0.40) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4196173 | 0.77 | SLC22A12 (0.39) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11544887 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL717257 | 0.73 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11542763 | 0.72 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4187011 | 0.71 | L3MBTL1 (0.42) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11307102 | 0.71 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4179901 | 0.71 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18045173 | 0.71 | ALDH1A1 (0.77) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11375359 | 0.70 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664011-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1664011-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020917-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |