Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584043 | 0.86 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL3587162 | 0.81 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4915021 | 0.80 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL4192316 | 0.80 | SMN1; SMN2 (0.57) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4188209 | 0.78 | MAPT (0.70) | RAB9ANPC1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL4199045 | 0.77 | THRB (0.56) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4193281 | 0.76 | MAPT (0.59) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| Cyclohexane Carboxamide SCHEMBL4191525 | 0.75 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4197928 | 0.75 | NPC1 (0.67) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4199074 | 0.74 | MAPT (0.57) | RAB9ANPC1SMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | claimed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | claimed |