Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 7/20 | 0.34 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.34 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3199721 | 0.84 | PDE10A (0.40) | PDE10AKCNN3KCNN1KCNN2DPP4 | |
| SCHEMBL8191475 | 0.78 | PDE10A (0.42) | PDE10AKCNN3KCNN1KCNN2DPP4 | |
| SCHEMBL4187704 | 0.76 | PDE10A (0.41) | PDE10AKCNN3KCNN1KCNN2DPP4 | |
| SCHEMBL22978862 | 0.75 | PDE10A (0.40) | PDE10AKCNN3KCNN1KCNN2DPP4 | |
| SCHEMBL3198220 | 0.74 | PDE10A (0.39) | PDE10AKCNN3KCNN1KCNN2DPP4 | |
| SCHEMBL14013841 | 0.70 | PDE10A (0.33) | PDE10ADPP4 | |
| SCHEMBL1487743 | 0.69 | PDE10A (0.47) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL15690186 | 0.69 | PDE10A (0.47) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL22979868 | 0.69 | KCNN3 (0.36) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL22979871 | 0.69 | KCNN3 (0.36) | PDE10AKCNN3KCNN1KCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054472-A1 | Pyrazolopyrimidine Derivatives or Pharmaceutically Acceptable Salts Thereof | TEIJIN PHARMA LIMITED (JP) | 2009-02-26 | — | — | US | disclosed |
| US-7473694-B2 | Pyrazolopyrimidine derivatives or pharmaceutically acceptable salts thereof | TEIJIN PHARMA LIMITED (JP) | 2009-01-06 | — | — | US | disclosed |
| EP-1864986-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2007-12-12 | — | — | EP | disclosed |
| US-20070173519-A1 | Pyrazolopyrimidine derivatives or pharmaceutically acceptable salts thereof | TEIJIN PHARMA LIMITED | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054472-A1 | Pyrazolopyrimidine Derivatives or Pharmaceutically Acceptable Salts Thereof | MAPKAPK2, MAPKAPK5, MAPKAPK3 | PDE10A 2033/4885KCNN3 752/4885KCNN1 669/4885 |
| US-20070173519-A1 | Pyrazolopyrimidine derivatives or pharmaceutically acceptable salts thereof | MAPKAPK2, MAPKAPK5, MAPKAPK3 | PDE10A 2033/4885KCNN3 752/4885KCNN1 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.