Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 5/20 | 0.36 |
| ▸ | CBLB | Q13191 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.33 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.33 |
| ▸ | CDK9 | P50750 | 5/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CCND1 | P24385 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22979868 | 1.00 | KCNN3 (0.36) | KCNN3CBLBPDE4BPDE4DKCNN1 | |
| SCHEMBL22996561 | 0.84 | PCSK9 (0.41) | KCNN3 | |
| SCHEMBL22979591 | 0.76 | NPC1 (0.35) | KCNN3CBLBNPC1RAB9AALDH1A1 | |
| SCHEMBL22979593 | 0.76 | NPC1 (0.35) | KCNN3CBLBNPC1RAB9AALDH1A1 | |
| SCHEMBL5445372 | 0.72 | PDE10A (0.43) | KCNN3KCNN1KCNN2CDK2PDE10A | |
| SCHEMBL3198220 | 0.71 | PDE10A (0.39) | KCNN3KCNN1KCNN2PDE10A | |
| SCHEMBL4196336 | 0.69 | PDE10A (0.40) | KCNN3KCNN1KCNN2PDE10A | |
| SCHEMBL22978862 | 0.69 | PDE10A (0.40) | KCNN3KCNN1KCNN2PDE10A | |
| SCHEMBL2044748 | 0.68 | KDM4E (0.42) | KCNN3PDE10AALDH1A1 | |
| SCHEMBL8205255 | 0.68 | PDE10A (0.36) | KCNN3PDE4BPDE4DKCNN1KCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027503-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND INTERMEDIATE AND USE THEREOF | 罗欣药业(上海)有限公司 | 2021-02-18 | — | — | WO | disclosed |