Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10813004 | 0.78 | CHRNA7 (0.41) | ACHENFE2L2ALDH1A1MAPT | |
| SCHEMBL16798345 | 0.76 | CA1 (0.52) | AOC3ACHEHTTALDH1A1MAPT | |
| SCHEMBL16798444 | 0.76 | SLC6A4 (0.48) | AOC3IDO1TDO2SLC6A3SLC6A2 | |
| SCHEMBL28835630 | 0.76 | TDP1 (0.42) | ACHEALDH1A1MAPTTSHRMAPK1 | |
| SCHEMBL16952921 | 0.76 | CES2 (0.38) | SLC6A4NFE2L2ALDH1A1MAPTCYP2C19 | |
| SCHEMBL7327576 | 0.75 | KMT2A (0.41) | CYP2D6TSHRHRH1LMNA | |
| SCHEMBL6205426 | 0.75 | AOC3 (0.47) | AOC3IDO1TDO2SLC6A3SLC6A2 | |
| SCHEMBL792136 | 0.75 | IDO1 (0.58) | AOC3IDO1TDO2SLC6A3SLC6A2 | |
| SCHEMBL27238 | 0.75 | KMT2A (0.41) | CYP2D6TSHRHRH1LMNA | |
| SCHEMBL16950984 | 0.74 | AOC3 (0.50) | AOC3IDO1TDO2ACHENFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1034501-C | (Bemzhydryloxyethylpiperidyl) aliphatic acid derivatives and their use in the treatment of allergies and asthma | SANKYO CO (JP) | 1997-04-09 | — | — | CN | claimed |
| CN-1058773-A | (diphenyl-methyl oxyethyl group piperidyl) aliphatic acid derivative and the purposes in treatment allergy and asthma thereof | SANKYO CO (JP) | 1992-02-19 | — | — | CN | claimed |
| EP-1796675-A4 | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES | MERCK & CO INC (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1796675-A2 | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES | Merck & Co., Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006039252-A2 | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES | MERCK & CO., INC. (US) | 2006-04-13 | — | — | WO | disclosed |
| EP-0906308-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES AS 5-HT1D RECEPTOR AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1999-04-07 | — | — | EP | disclosed |
| EP-0861244-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997045426-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES AS 5-HT1D RECEPTOR AGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-12-04 | — | — | WO | disclosed |
| EP-0804434-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1997-11-05 | — | — | EP | disclosed |
| WO-1997018201-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-22 | — | — | WO | disclosed |
| CN-1034501-C | (Bemzhydryloxyethylpiperidyl) aliphatic acid derivatives and their use in the treatment of allergies and asthma | SANKYO CO (JP) | 1997-04-09 | — | — | CN | disclosed |
| WO-1996004274-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-15 | — | — | WO | disclosed |
| CN-1058773-A | (diphenyl-methyl oxyethyl group piperidyl) aliphatic acid derivative and the purposes in treatment allergy and asthma thereof | SANKYO CO (JP) | 1992-02-19 | — | — | CN | disclosed |