Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.81 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581588 | 0.86 | SMN1; SMN2 (0.71) | SMN1; SMN2NPSR1RAB9AALDH1A1CNR1 | |
| SCHEMBL3584894 | 0.85 | RAB9A (0.80) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 | |
| SCHEMBL27727764 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2NPSR1RAB9AALDH1A1CNR1 | |
| SCHEMBL3585640 | 0.83 | RAB9A (0.81) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 | |
| SCHEMBL3582729 | 0.81 | NPC1 (0.73) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 | |
| SCHEMBL4184590 | 0.80 | RAB9A (0.58) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 | |
| SCHEMBL4195858 | 0.80 | RAB9A (0.57) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 | |
| SCHEMBL27840325 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 | |
| SCHEMBL4914698 | 0.79 | KMT2A (0.53) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 | |
| SCHEMBL14346433 | 0.79 | RAB9A (0.63) | SMN1; SMN2NPSR1RAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | disclosed |