Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2422778 | 0.89 | MEN1 (0.51) | MEN1KMT2AABCG2LMNAMAPK1 | |
| SCHEMBL2425351 | 0.88 | MEN1 (0.49) | MEN1KMT2AABCG2LMNAMAPT | |
| SCHEMBL2423145 | 0.88 | MEN1 (0.46) | MEN1KMT2ALMNAUSP2MAPT | |
| SCHEMBL2419313 | 0.84 | MEN1 (0.49) | MEN1KMT2AABCG2LMNAMAPT | |
| SCHEMBL4968428 | 0.84 | MEN1 (0.44) | MEN1KMT2AABCG2LMNAMAPT | |
| SCHEMBL4190631 | 0.83 | KMT2A (0.49) | MEN1KMT2ALMNAUSP2MAPT | |
| SCHEMBL6432002 | 0.83 | MEN1 (0.43) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL2419255 | 0.82 | MEN1 (0.46) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL2420616 | 0.82 | KMT2A (0.53) | MEN1KMT2AABCG2LMNAMAPT | |
| SCHEMBL7439566 | 0.81 | MAPK9 (0.48) | MEN1KMT2ALMNAUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |