Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11974037 | 0.87 | POLB (0.58) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL16256877 | 0.87 | LMNA (0.58) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL4193322 | 0.86 | LMNA (0.54) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL7448604 | 0.84 | LMNA (0.55) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL28787851 | 0.83 | POLB (0.54) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL27793040 | 0.82 | POLB (0.52) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL725320 | 0.81 | LMNA (0.58) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL31282160 | 0.81 | GNAO1 (0.60) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL27028419 | 0.81 | LMNA (0.51) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL4193447 | 0.81 | LMNA (0.51) | LMNAPOLBSMN1; SMN2GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032559-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138268-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |