Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.82 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.82 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2138822 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL342742 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL30743784 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL342743 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL2139580 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL532168 | 0.95 | — | — | |
| Maleic Acid SCHEMBL988578 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL985495 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL2548587 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5684333 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106370320-A | Super-cooled temperature monitoring method based on shape memory alloy | 沈阳建筑大学 | 2017-02-01 | — | — | CN | claimed |
| CN-103957991-B | Insert the medical treatment device in human body or animal body | 马维斯医疗股份有限公司 | 2016-08-24 | — | — | CN | claimed |
| CN-103957991-A | Medical device for insertion into the human or animal body | MARVIS MEDICAL GMBH | 2014-07-30 | — | — | CN | claimed |
| US-20080075957-A1 | Heating separate reducing solutions of core and shell precursors (ferric acetylacetone; cadmium acetate and selenium, respectively); cooling, mixing the two solutions to effect precipitation (cadmium selenide-coated magnetite); high crystallization degree; uniform size; high chemical stability | KOREA UNIVERSITY FOUNDATION (KR) | 2008-03-27 | — | — | US | claimed |
| CN-106370320-A | Super-cooled temperature monitoring method based on shape memory alloy | 沈阳建筑大学 | 2017-02-01 | — | — | CN | disclosed |
| CN-106158201-A | Magnetic anisotropy rare-earth iron-boron permanent-magnet alloy submicron particles and preparation method thereof | 中国科学院宁波材料技术与工程研究所 | 2016-11-23 | — | — | CN | disclosed |
| CN-106128753-A | A kind of method preparing FePt counterfeit Spin Valve material | 北京科技大学 | 2016-11-16 | — | — | CN | disclosed |
| CN-103957991-B | Insert the medical treatment device in human body or animal body | 马维斯医疗股份有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104014802-B | A kind of method that aerosol auxiliary prepares nanometer monocrystalline granule | 常州大学 | 2016-08-17 | — | — | CN | disclosed |
| CN-105228688-A | Vascular treatment device and method | INSERA THERAPEUTICS INC | 2016-01-06 | — | — | CN | disclosed |
| CN-105025947-A | Method of fabricating an implantable medical device comprising a rapamycin derivative | ABBOTT CARDIOVASCULAR SYSTEMS | 2015-11-04 | — | — | CN | disclosed |
| CN-104684543-A | Formulation for the delivery of nucleotide sequences that can modulate endogenous interfering RNA mechanisms | COMMISSARIAT ENERGIE ATOMIQUE | 2015-06-03 | — | — | CN | disclosed |
| CN-103961085-A | Sensor Platform and Method of Preparing the Same | SAMSUNG ELECTRONICS CO LTD | 2014-08-06 | — | — | CN | disclosed |
| US-8445981-B2 | Magnetic memory devices, electronic systems and memory cards including the same, methods of manufacturing the same, and methods of forming a perpendicular magnetic film of the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2013-05-21 | — | — | US | disclosed |
| CN-102920500-A | Skeletal manipulation method | ELLIPSE TECHNOLOGIES INC | 2013-02-13 | — | — | CN | disclosed |
| CN-101917918-B | Skeletal manipulation system | ELLIPSE TECHNOLOGIES INC | 2012-11-21 | — | — | CN | disclosed |
| US-20120018825-A1 | MAGNETIC MEMORY DEVICES, ELECTRONIC SYSTEMS AND MEMORY CARDS INCLUDING THE SAME, METHODS OF MANUFACTURING THE SAME, AND METHODS OF FORMING A PERPENDICULAR MAGNETIC FILM OF THE SAME | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2012-01-26 | — | — | US | disclosed |
| CN-102056575-A | Method of loading a medical device into a delivery system | COOK INC | 2011-05-11 | — | — | CN | disclosed |
| CN-101917918-A | Skeletal manipulation system | ELLIPSE TECHNOLOGIES INC | 2010-12-15 | — | — | CN | disclosed |
| US-20070274193-A1 | Information recording and reproducing apparatus | KABUSHIKI KAISHA TOSHIBA (JP) | 2007-11-29 | — | — | US | disclosed |