Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2139580 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL2138822 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL342742 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL342743 | 1.00 | — | — | |
| Maleic Acid SCHEMBL988578 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL2548589 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL6732597 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL985495 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL6386749 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL419688 | 0.95 | TSHR (0.82) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118022775-A | Catalyst for catalytic oxidative cracking of hydrogen sulfide and simultaneous production of hydrogen | 内斯特化学技术股份有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-111715242-B | Catalyst for sulfur recovery method for simultaneous production of hydrogen and method for producing the same | 代表MT创新中心的斯塔米卡邦有限公司 | 2024-03-08 | — | — | CN | claimed |
| EP-3806999-A1 | CATALYST FOR CATALYTIC OXIDATIVE CRACKING OF HYDROGEN SULPHIDE WITH CONCURRENT HYDROGEN PRODUCTION | NextChem S.p.A. (IT) | 2021-04-21 | — | — | EP | claimed |
| CN-112601610-A | Catalyst for the catalytic oxidative cracking of hydrogen sulphide with simultaneous production of hydrogen | 内斯特化学股份有限公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3760309-A1 | METHOD OF MAKING A CATALYST FOR A SULPHUR RECOVERY PROCESS WITH CONCURRENT HYDROGEN PRODUCTION; CATALYST, AND HYDROGEN PRODUCTION METHOD | Stamicarbon B.V. acting under the name of MT Innovation Center (NL) | 2021-01-06 | — | — | EP | claimed |
| CN-111715242-A | Catalyst for sulfur recovery process for simultaneous production of hydrogen and process for producing the same | 代表MT创新中心的斯塔米卡邦有限公司 | 2020-09-29 | — | — | CN | claimed |
| EP-2490989-B1 | PRODUCTION OF LOWER OLEFINS FROM SYNTHESIS GAS | NEDERLANDSE ORGANISATIE VOOR WETENSCHAPPELIJK ONDERZOEK NWO (NL) | 2020-02-12 | — | — | EP | claimed |
| US-9981253-B2 | Catalyst for a sulphur recovery process with concurrent hydrogen production, method of making thereof and the sulphur recovery process with concurrent hydrogen production using the catalyst | STAMICARBON B.V. ACTING UNDER THE NAME OF MT INNOVATION CENTER (NL) | 2018-05-29 | — | — | US | claimed |
| CN-106848242-A | A kind of organic lithium storage materials of high power capacity and its application | 苏州大学 | 2017-06-13 | — | — | CN | claimed |
| US-20170106355-A1 | CATALYST FOR A SULPHUR RECOVERY PROCESS WITH CONCURRENT HYDROGEN PRODUCTION, METHOD OF MAKING THEREOF AND THE SULPHUR RECOVERY PROCESS WITH CONCURRENT HYDROGEN PRODUCTION USING THE CATALYST | STAMICARBON B.V. ACTING UNDER THE NAME OF MT INNOVATION CENTER (NL) | 2017-04-20 | — | — | US | claimed |
| US-8703830-B2 | Production of lower olefins from synthesis gas | NETHERLANDS ORGANISATION FOR SCIENTIFIC RESEARCH (ADVANCED CHEMICAL TECHNOLOGIES FOR SUSTAINABILITY) (NL) | 2014-04-22 | — | — | US | claimed |
| US-20120259026-A1 | PRODUCTION OF LOWER OLEFINS FROM SYNTHESIS GAS | NEDERLANDSE ORGANISATIE VOOR WETENSCHAPPELIJK ONDERZOEK (NWO) (NL) | 2012-10-11 | — | — | US | claimed |
| EP-2490989-A1 | PRODUCTION OF LOWER OLEFINS FROM SYNTHESIS GAS | Netherlands Organisation for Scientific Research (Advanced Chemical Technologies for Sustainability) (NL) | 2012-08-29 | — | — | EP | claimed |
| WO-2011049456-A1 | PRODUCTION OF LOWER OLEFINS FROM SYNTHESIS GAS | NETHERLANDS ORGANISATION FOR SCIENTIFIC RESEARCH (ADVANCED CHEMICAL TECHNOLOGIES FOR SUSTAINABILITY) (NL) | 2011-04-28 | — | — | WO | claimed |
| EP-2314557-A1 | Production of lower olefins from synthesis gas | Netherlands Organisation for Scientific Research (Advanced Chemical Technologies for Sustainability) (NL) | 2011-04-27 | — | — | EP | claimed |
| CN-1718699-A | Catalytic combustion adjuvant for coal | YIN XIAOLIN (CN) | 2006-01-11 | — | — | CN | claimed |
| US-6486367-B1 | Process for the hydrogenation of maleic acid to 1,4-butanediol | THE STANDARD OIL COMPANY | 2002-11-26 | — | — | US | claimed |
| EP-0919530-B1 | Improved process for the hydrogenation of maleic acid to 1,4-butanediol | STANDARD OIL CO (US) | 2002-02-13 | — | — | EP | claimed |
| EP-0919530-A1 | Improved process for the hydrogenation of maleic acid to 1,4-butanediol | THE STANDARD OIL COMPANY (US) | 1999-06-02 | — | — | EP | claimed |
| US-4624942-A | Iron on mixed zirconia-titania substrate Fischer-Tropsch catalyst and method of making same | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1986-11-25 | — | — | US | claimed |