Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.47 |
| ▸ | THRA | P10827 | 9/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282210 | 0.84 | THRB (0.53) | THRBTHRA | |
| SCHEMBL31041250 | 0.84 | THRB (0.53) | THRBTHRA | |
| SCHEMBL4189061 | 0.78 | THRB (0.40) | THRBTHRAOPRM1OPRD1OPRK1 | |
| SCHEMBL3165952 | 0.75 | THRB (0.53) | THRBTHRA | |
| SCHEMBL4210590 | 0.75 | THRB (0.42) | THRBTHRA | |
| SCHEMBL3162167 | 0.75 | THRB (0.59) | THRBTHRAPPARGPPARDPPARA | |
| SCHEMBL282199 | 0.74 | THRB (0.56) | THRBTHRA | |
| SCHEMBL4199500 | 0.74 | THRB (0.41) | THRBTHRA | |
| SCHEMBL3886500 | 0.74 | THRB (0.57) | THRBTHRA | |
| SCHEMBL283051 | 0.72 | OPRK1 (0.39) | THRBTHRAPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689383-A4 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1689383-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051298-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2005-06-09 | — | — | WO | disclosed |