Histidine

Histidine

SCHEMBL4197041

NCl.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.45
CYP3A4 P08684 2/20 0.45
CYP1A2 P05177 1/20 0.44
PKM P14618 2/20 0.41
ALPI P09923 1/20 0.41
PTGS1 P23219 1/20 0.41
XIAP P98170 1/20 0.41
GRIA2 P42262 4/20 0.39
GRIA1 P42261 3/20 0.39
GRIA3 P42263 3/20 0.39
GRIA4 P48058 3/20 0.39
HSD17B10 Q99714 2/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
KDM4E B2RXH2 2/20 0.38
LMNA P02545 2/20 0.38
MAPT P10636 2/20 0.38
BLM P54132 2/20 0.38
PMP22 Q01453 2/20 0.38
HIF1A Q16665 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL4197034 1.00 SLC7A5 (0.45) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL1086600 0.97 SLC7A5 (0.45) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL28554820 0.97 SLC7A5 (0.45) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL388561 0.97 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL3259 0.97 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL3258 0.97 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL388563 0.97 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL163442 0.97 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL18824897 0.97 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2PKMALPI
Histidine SCHEMBL8316642 0.97 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2PKMALPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1221985-B1 CONVEYANCE OF ANTI-INFECTIVE ACTIVITY TO WOUND DRESSINGS BOSTON SCIENT SCIMED INC (US) 2009-03-11 EP disclosed
US-6939569-B1 Medical device having anti-infective and contraceptive properties OXIBIO, INC. (US) 2005-09-06 US disclosed
EP-1087800-B1 IMPLANTABLE MEDICAL DEVICE HAVING ANTI-INFECTIVE AND CONTRACEPTIVE PROPERTIES OXIBIO INC (US) 2003-08-06 EP disclosed
US-6592890-B1 Generating iodine within injury site from reaction with blood glucose; containing such an inorganic iodide, glucose oxidase and a peroxidase; stable; efficient; sustained release OXIBIO, INC. 2003-07-15 US disclosed
EP-1221985-A1 CONVEYANCE OF ANTI-INFECTIVE ACTIVITY TO WOUND DRESSINGS Oxibio, Inc. (US) 2002-07-17 EP disclosed
CN-1306444-A Medical device having anti-infective and contraceptive properties OXIBIO INC (US) 2001-08-01 CN disclosed
WO-2001028600-A1 CONVEYANCE OF ANTI-INFECTIVE ACTIVITY TO WOUND DRESSINGS OXIBIO, INC. (US) 2001-04-26 WO disclosed
EP-1087800-A1 MEDICAL DEVICE HAVING ANTI-INFECTIVE AND CONTRACEPTIVE PROPERTIES Oxibio, Inc. (US) 2001-04-04 EP disclosed
WO-1999065538-A9 MEDICAL DEVICE HAVING ANTI-INFECTIVE AND CONTRACEPTIVE PROPERTIES OXIBIO INC (US) 2000-10-12 WO disclosed
WO-1999065538-A1 MEDICAL DEVICE HAVING ANTI-INFECTIVE AND CONTRACEPTIVE PROPERTIES OXIBIO, INC. (US) 1999-12-23 WO disclosed