Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 8/20 | 0.41 |
| ▸ | FDPS | P14324 | 9/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9451730 | 0.79 | ANPEP (0.42) | ANPEPFDPSERAP2 | |
| SCHEMBL7074253 | 0.77 | ANPEP (0.64) | ANPEPFDPSERAP2 | |
| SCHEMBL11660087 | 0.76 | ANPEP (0.44) | ANPEPFDPSERAP2 | |
| SCHEMBL7538729 | 0.74 | ANPEP (0.58) | ANPEPFDPSERAP2 | |
| SCHEMBL5935325 | 0.74 | FOLH1 (0.41) | ANPEPFDPS | |
| SCHEMBL7565355 | 0.73 | — | — | |
| SCHEMBL4102805 | 0.73 | FDPS (0.39) | ANPEPFDPSERAP2 | |
| SCHEMBL8672148 | 0.72 | ANPEP (0.37) | ANPEPFDPSERAP2 | |
| SCHEMBL10885760 | 0.72 | ANPEP (0.37) | ANPEPFDPSERAP2 | |
| SCHEMBL8675610 | 0.71 | FDPS (0.48) | ANPEPFDPSERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471921-B1 | COUNTERACTING BIOPROSTHETIC CALCIFICATION | PHILADELPHIA CHILDREN HOSPITAL (US) | 2009-03-11 | — | — | EP | claimed |
| US-7156881-B2 | Counteracting bioprosthetic calcification | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2007-01-02 | — | — | US | claimed |
| US-20030196274-A1 | Counteracting bioprosthetic calcification | CHILDREN'S HOSPITAL OF PHILADELPHIA | 2003-10-23 | — | — | US | claimed |
| EP-1471921-B1 | COUNTERACTING BIOPROSTHETIC CALCIFICATION | PHILADELPHIA CHILDREN HOSPITAL (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1471921-A4 | COUNTERACTING BIOPROSTHETIC CALCIFICATION | PHILADELPHIA CHILDREN HOSPITAL (US) | 2007-06-20 | — | — | EP | disclosed |
| US-7156881-B2 | Counteracting bioprosthetic calcification | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2007-01-02 | — | — | US | disclosed |
| US-7156881-B2 | Counteracting bioprosthetic calcification | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2007-01-02 | — | — | US | disclosed |
| EP-1471921-A2 | COUNTERACTING BIOPROSTHETIC CALCIFICATION | The Children's Hospital of Philadelphia (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20030196274-A1 | Counteracting bioprosthetic calcification | CHILDREN'S HOSPITAL OF PHILADELPHIA | 2003-10-23 | — | — | US | disclosed |
| WO-2003057177-A2 | COUNTERACTING BIOPROSTHETIC CALCIFICATION | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2003-07-17 | — | — | WO | disclosed |