Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ITK | Q08881 | 1/20 | 0.57 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522207 | 0.84 | EGFR (0.61) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL10404298 | 0.80 | KMT2A (0.67) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL31129249 | 0.80 | KMT2A (0.67) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL50309 | 0.80 | KMT2A (0.67) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3761569 | 0.80 | KMT2A (0.68) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL22874394 | 0.80 | TGM2 (0.54) | RAB9ANPC1LMNAKDM4ETGM2 | |
| SCHEMBL28524018 | 0.79 | EGFR (0.49) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL22773569 | 0.79 | KMT2A (0.65) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL28534540 | 0.79 | TGM2 (0.56) | LMNATGM2EGFRITK | |
| Hydrochloric Acid SCHEMBL38658753 | 0.79 | KMT2A (0.66) | RAB9ANPC1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648448-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | claimed |
| EP-1648448-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005011681-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | claimed |
| CN-111875585-B | Kinase inhibitors | 上海艾力斯医药科技股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-112409360-B | Heteroaryl vinyl xanthine derivatives and uses thereof | 广东东阳光药业有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-112409360-A | Heteroaryl vinyl xanthine derivatives and uses thereof | 广东东阳光药业有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-111892579-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-111875585-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-106660993-B | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-09-11 | — | — | CN | disclosed |