Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030252 | 0.84 | SCARB1 (0.70) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL13747090 | 0.83 | SCARB1 (0.60) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL4028758 | 0.83 | SCARB1 (0.72) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL4024931 | 0.83 | SCARB1 (0.69) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL4189175 | 0.83 | SCARB1 (0.69) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL4029504 | 0.82 | SCARB1 (0.68) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL4195549 | 0.82 | SCARB1 (0.68) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL4028396 | 0.80 | SCARB1 (0.66) | SCARB1HSD17B10HDAC1HDAC6NPC1 | |
| SCHEMBL4728860 | 0.80 | SCARB1 (0.61) | SCARB1PTGDR2RXFP1RORC | |
| SCHEMBL4728754 | 0.79 | SCARB1 (0.60) | SCARB1HSD17B10HDAC1HDAC6PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |