Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3211606 | 0.78 | SIGMAR1 (0.69) | SIGMAR1POLBMAPK14HTTKMT2A | |
| SCHEMBL3133105 | 0.78 | SIGMAR1 (0.58) | SIGMAR1POLBMAPK14HTTKMT2A | |
| SCHEMBL1332781 | 0.76 | ALDH1A1 (0.56) | MAPK14MAPK13MAPK12MAPK11HTT | |
| SCHEMBL3135136 | 0.76 | SIGMAR1 (0.56) | SIGMAR1POLBMAPK14HTTKMT2A | |
| SCHEMBL31485199 | 0.73 | IRAK4 (0.49) | MAPK14MAPK13MAPK12MAPK11LCK | |
| SCHEMBL27338664 | 0.72 | SIGMAR1 (0.67) | SIGMAR1POLBHTTKMT2ADRD2 | |
| SCHEMBL1651281 | 0.72 | SIGMAR1 (0.67) | SIGMAR1POLBHTTKMT2ADRD2 | |
| SCHEMBL18757112 | 0.72 | SIGMAR1 (0.45) | SIGMAR1POLBMAPK14ABL1BCR | |
| SCHEMBL29615558 | 0.72 | HRH3 (0.57) | SIGMAR1HTTSRCKDM4EALDH1A1 | |
| SCHEMBL22918726 | 0.72 | HRH3 (0.57) | SIGMAR1HTTSRCKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027087-A2 | INTRACELLULAR KINASE INHIBITORS | MannKind Corporation (US) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007136790-A2 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |