Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.74 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 2/20 | 0.56 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463870 | 0.92 | PTGS2 (0.72) | MAPTKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL27475606 | 0.91 | MAPT (0.67) | MAPTKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL19769223 | 0.86 | MAPT (0.93) | MAPTKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL4193885 | 0.84 | IKBKB (0.72) | MAPTKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL30701209 | 0.82 | HPGD (0.71) | MAPTKMT2AMEN1TDP1KDM4E | |
| SCHEMBL15583810 | 0.82 | HPGD (0.71) | MAPTKMT2AMEN1TDP1KDM4E | |
| SCHEMBL6220216 | 0.82 | KMT2A (0.63) | MAPTKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL27473109 | 0.81 | LIMK1 (0.57) | MAPTKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL27473521 | 0.80 | MAPT (0.56) | MAPTKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL4198643 | 0.78 | MAPT (0.85) | MAPTKMT2AMEN1TDP1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029608-A1 | SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXAMIDE COMPOUNDS, THEIR PREPARATION AND USE | Boehringer Ingelheim International GmbH (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007146602-A1 | SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXAMIDE COMPOUNDS, THEIR PREPARATION AND USE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |