Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 15/20 | 0.71 |
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15583810 | 1.00 | HPGD (0.71) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL27473523 | 0.92 | HPGD (0.70) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL27475606 | 0.91 | MAPT (0.67) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL6216343 | 0.90 | HPGD (0.68) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL16557518 | 0.88 | HPGD (0.71) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL21589903 | 0.87 | HPGD (0.65) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL6217262 | 0.86 | MAPT (0.86) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL15583949 | 0.85 | HPGD (0.93) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL6215605 | 0.85 | ALDH1A1 (0.73) | HPGDMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL30701120 | 0.85 | HPGD (0.93) | HPGDMAPTKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2024-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | HPGD 2/4885MAPT 4311/4885KDM4E 3434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.