Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.33 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421857 | 0.85 | HSP90AA1 (0.51) | HSP90AA1NR3C1BIRC5PDGFRBPDGFRA | |
| SCHEMBL950675 | 0.84 | HSP90AA1 (0.49) | HSP90AA1NR3C1BIRC5PDGFRBPDGFRA | |
| SCHEMBL951332 | 0.83 | BIRC5 (0.37) | HSP90AA1BIRC5PDGFRBPDGFRAAR | |
| SCHEMBL2183124 | 0.82 | BIRC5 (0.38) | HSP90AA1NR3C1BIRC5PDGFRBPDGFRA | |
| SCHEMBL425541 | 0.82 | HSP90AA1 (0.51) | HSP90AA1BIRC5ABCG2NPC1MAPT | |
| SCHEMBL2183119 | 0.82 | BIRC5 (0.37) | HSP90AA1NR3C1BIRC5PDGFRBPDGFRA | |
| SCHEMBL422414 | 0.81 | BIRC5 (0.41) | BIRC5PDGFRBPDGFRAARPIK3CA | |
| SCHEMBL1394564 | 0.80 | HSP90AA1 (0.46) | HSP90AA1NR3C1BIRC5ARNPC1 | |
| SCHEMBL1395324 | 0.79 | HSP90AA1 (0.74) | HSP90AA1 | |
| SCHEMBL1395321 | 0.79 | HSP90AA1 (0.74) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102439003-A | Indazole derivatives inhibiting HSP90, compositions containing said derivatives and uses thereof | SANOFI AVENTIS | 2012-05-02 | — | — | CN | disclosed |
| EP-2408762-A1 | HSP90 INHIBITING INDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI (FR) | 2012-01-25 | — | — | EP | disclosed |
| US-20120010241-A1 | HSP90 INHIBITING INDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI (FR) | 2012-01-12 | — | — | US | disclosed |
| WO-2010106290-A1 | HSP90 INHIBITING INDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010241-A1 | HSP90 INHIBITING INDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885NR3C1 34/4885BIRC5 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.