Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL3 | P20749 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188676 | 0.91 | DRD3 (0.56) | BCL3ALDH1A1GAADRD3POLB | |
| SCHEMBL17554166 | 0.86 | BCL3 (0.73) | BCL3ALDH1A1GAAPOLBHTT | |
| SCHEMBL5256886 | 0.85 | TSHR (0.58) | ALDH1A1GAATSHRPOLBKDM4E | |
| SCHEMBL29849602 | 0.83 | BCL3 (0.74) | BCL3ALDH1A1GAATSHRPOLB | |
| SCHEMBL16430547 | 0.83 | BCL3 (0.74) | BCL3ALDH1A1GAATSHRPOLB | |
| SCHEMBL5223641 | 0.83 | PPARG (0.52) | ALDH1A1GAADRD3TSHRPOLB | |
| SCHEMBL5795351 | 0.83 | KMT2A (0.63) | BCL3ALDH1A1HTTKDM4E | |
| SCHEMBL31518356 | 0.83 | KMT2A (0.63) | BCL3ALDH1A1HTTKDM4E | |
| SCHEMBL17554045 | 0.83 | BCL3 (0.70) | BCL3ALDH1A1RXFP1DRD3TSHR | |
| SCHEMBL5225535 | 0.81 | TSHR (0.50) | ALDH1A1GAATSHRPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |