Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192846 | 0.85 | ALDH1A1 (0.47) | PPARGALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL4188676 | 0.85 | DRD3 (0.56) | ALDH1A1DRD3KMT2AGAAHSD17B10 | |
| SCHEMBL4200900 | 0.83 | BCL3 (0.61) | ALDH1A1DRD3GAATSHRPOLB | |
| SCHEMBL4193276 | 0.83 | ALDH1A1 (0.45) | PPARGALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL4199022 | 0.82 | CNR1 (0.64) | ALDH1A1NPC1HPGD | |
| SCHEMBL4000293 | 0.80 | TAAR1 (0.50) | ALDH1A1TAAR1ADORA2AGAAMAPT | |
| SCHEMBL5225535 | 0.78 | TSHR (0.50) | ALDH1A1KMT2AMEN1RAB9AGAA | |
| SCHEMBL4196595 | 0.78 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1NPC1HPGD | |
| SCHEMBL10902462 | 0.78 | HPGD (0.66) | PPARGALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4191620 | 0.78 | POLB (0.63) | ALDH1A1KMT2AMEN1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |