Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256886 | 0.82 | TSHR (0.58) | TSHRPOLBALDH1A1GAAMEN1 | |
| SCHEMBL4200900 | 0.81 | BCL3 (0.61) | TSHRPOLBALDH1A1GAAKDM4E | |
| SCHEMBL5224971 | 0.80 | ALDH1A1 (0.43) | TSHRALDH1A1NPC1MAPTGAA | |
| SCHEMBL4194329 | 0.80 | CHRNA7 (0.56) | — | |
| SCHEMBL5236479 | 0.78 | CNR1 (0.73) | CNR1CNR2ALDH1A1NPC1MAPT | |
| SCHEMBL5223641 | 0.78 | PPARG (0.52) | TSHRPOLBALDH1A1NPC1MAPT | |
| SCHEMBL4199022 | 0.78 | CNR1 (0.64) | CNR1CNR2ALDH1A1NPC1HPGD | |
| SCHEMBL4196595 | 0.78 | ALDH1A1 (0.57) | TSHRPOLBCNR1CNR2ALDH1A1 | |
| SCHEMBL4192978 | 0.76 | ALDH1A1 (0.49) | TSHRPOLBCNR1CNR2ALDH1A1 | |
| SCHEMBL13162874 | 0.76 | TAS1R3 (0.47) | TSHRALDH1A1NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |