Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.80 |
| ▸ | GAA | P10253 | 8/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3585297 | 0.81 | SMN1; SMN2 (0.71) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5911664 | 0.79 | ALDH1A1 (0.77) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5912285 | 0.78 | ALDH1A1 (0.81) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1540449 | 0.77 | ALDH1A1 (0.49) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27706868 | 0.77 | SMN1; SMN2 (0.76) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11893065 | 0.76 | CA1 (0.60) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2370145 | 0.75 | ALDH1A1 (0.53) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5911686 | 0.75 | ALDH1A1 (0.73) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5911650 | 0.74 | KMT2A (0.87) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3579796 | 0.74 | NPC1 (0.79) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | disclosed |