Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199061 | 0.87 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3577640 | 0.85 | SCD (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL774334 | 0.85 | LCK (0.73) | RAB9ANPC1SMN1; SMN2LCK | |
| SCHEMBL27706969 | 0.85 | HDAC3 (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3581996 | 0.84 | KDM4E (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3581515 | 0.84 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4899528 | 0.84 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4187271 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3582729 | 0.82 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4200739 | 0.82 | MEN1 (0.69) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | disclosed |